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June 27, 2015


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It's time to... get your GUT in gear!  Intestinal fortitude has an all new meaning!

ProBio Plex is Aviv's answer to building a strong happy healthy friendly microbial force which will restore your gastrointestinal balance and build overall immune health.

ProBio Plex contains 30 billion rootin' tootin' probiotics
... a rich multistrain, multispecies blend of the most studied and safest probiotics on planet earth.  These probiotics are powerfully effective in their own right, but together, they have a well known synergistic effect which boosts good GUT flora (beneficial live microorganisms necessary for life) for more complete and productive digestion -- the very basis for good overall health.

80% of your immune system begins in your Gastrointestinal Tract!

More than 60 million Americans suffer from digestive disorders such as IBS (Irritable Bowel Syndrome), Leaky Gut Syndrome, constipation, diarrehea, gastroesophageal reflux disease, gas, bloating, yeast overgrowth...

"Bacteria adhere to the lining of the colon like icing on a cake,"
   - Dr. Richard Fedorak, Gastroenterologist -
Stated at Digestive Disease Week 2003
cake frosting clinging to layers similar to bacteria in colon

If you want to be healthy you need to have vast quantities of beneficial microorganisms -- PRObiotics -- in your digestive system. These friendly bacteria fight dangerous microbes, which cause diseases and infections. If you want your probiotics to survive, they need their food -- PREbiotics... introduced via supplement capsules or food (garlic...).  See our product SynBio Plex, which contains both pre and probiotics.  This is a great companion product to ProBio Plex.

To help fight disease, ease GUT issues, lower cholesterol and improve overall health it is best to use a quality multistrain, multispecies probiotic blend.  To further enhance the effects, and life span of probiotics, add a prebiotic to your daily regimen.  This can be done by adding fiberous foods, or foods like garlic, which is an excellent prebiotic and has very therapeutic properties of its own. 

If you are looking for a product which contains both prebiotics and probiotics in a convenient capsule form, take a look at our SynBio Plex.  Probio Plex and Synbio Plex actually work very well in unison.

ProBio Plex = Healthy Tummy = Healthy You!

Good bacteria are destroyed by antibiotics, alcohol, chlorine in water, smoking, non organic meat, too much sugar... among other things. (Not only does half-digested sugar kill off the good bacteria, but Candida Albicans also thrive on it... double-whammy.)
Save the tummy! Healthy intestinal tract equal healthy YOU!

Probiotics -- Friendly Bacteria for Your Gastroinstestinal Health

How a healthy gastrointestinal tract and good flora protect your health.

Each ProBio Plex Veggie Cap Contains:

Bacillus subtilis - DE111TM
    Bacillus coagulans
    Lactobacillus acidophilus
    Bifidobacterium lactis
    Bifidobacterium longum
    Lactobacillus rhamnosus
    Lactobacillus salivarius
    Lactobacillus casei
    Bifidobacterium breve
    Lactobacillus plantarum

DE111TM Bacillus subtilis is beneficial in many ways and is often used in industrial applications. It is known to be very safe and helps stabilize shelf life and potency of many products, including antibiotics.  It is used to produce a variety of enzymes, including amylase.

Bacillus coagulans is a type of beneficial bacteria. It is used similarly to lactobacillus and other probiotics as "good" bacteria.

People take Bacillus coagulans for diarrhea, including infectious types such as rotaviral diarrhea in children; traveler's diarrhea; and diarrhea caused by antibiotics. Bacillus coagulans is also used for general digestion problems, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD, Crohn's disease, ulcerative colitis), a bowel disorder called Clostridium difficile colitis, excessive growth of “bad” bacteria in short bowel syndrome, and infection due to the ulcer-causing bacterium Helicobacter pylori.

Some people use Bacillus coagulans to prevent respiratory infections and ramp up the immune system. It is also used to prevent cancer or the formation of cancer-causing agents. There is also some interest in using it as an additive to vaccines to improve their effectiveness.

Lactobacillus Acidophilus
thrives in the small intestine where it produces a number of antimicrobial compounds. These compounds help slow the growth of 23 known toxins and inhibit tumor and carginogenic growth. It also aids in producing Amylase, a carbohydrate reducing enzyme.

There are lots of different species of lactobacillus. These are "friendly" bacteria that normally live in our digestive, urinary, and genital systems without causing disease. Lactobacillus is also in some fermented foods like yogurt and in dietary supplements.

Lactobacillus is used for treating and preventing diarrhea, including infectious types such as rotaviral diarrhea in children and traveler's diarrhea. It is also used to prevent and treat diarrhea associated with using antibiotics.

Some people use lactobacillus for general digestion problems; irritable bowel syndrome (IBS); colic in babies; Crohn's disease; inflammation of the colon; and a serious gut problem called necrotizing enterocolitis (NEC) in babies born prematurely. Lactobacillus is also used for infection with Helicobacter pylori, the type of bacteria that causes ulcers, and also for other types of infections including urinary tract infections (UTIs), vaginal yeast infections, to prevent the common cold in adults, and to prevent respiratory infections in children attending daycare centers. It is also being tested to prevent serious infections in people on ventilators.

Lactobacillus is used for skin disorders such as fever blisters, canker sores, eczema (allergic dermatitis); and acne. It is also used for high cholesterol, lactose intolerance, Lyme disease, hives, and to boost the immune system. Lactobacillus is also used to treat vaginal infections and urinary tract infections (UTIs).

Bifidobacterium Lactis - Clinical research has shown that as people age, or when under stress, there is a decline in the number of Bifidobacteria in the large intestine.  Bifidobacteria are a group of bacteria that normally live in the intestines. They can be grown outside the body and then taken by mouth as medicine.

There is some evidence that there is prevention of a type of infection in the lining of the intestine caused by bacteria (necrotizing enterocolitis), particularly when used in combination with another bacterium called Lactobacillus acidophilus.

Bifidobacteria are used for many conditions affecting the intestines, including preventing diarrhea in infants and children; as well as traveler’s diarrhea in adults. Some people take bifidobacteria to restore “good bacteria” in the gut that have been killed or removed by diarrhea, radiation, chemotherapy, antibiotics, or other causes. Bifidobacteria are also used to treat a bowel disease called ulcerative colitis, as well as a condition called pouchitis, which sometimes develops after surgery for ulcerative colitis. Some people use Bifidobacteria to prevent a particular bowel infection called necrotizing enterocolitis in newborns.

Other uses for Bifidobacteria include treating a skin condition in infants called atopic eczema, yeast infections (candidiasis), cold, flu, reducing flu-like symptoms in children attending day-care centers, breast pain (mastitis), hepatitis, lactose intolerance, mumps, Lyme disease, and cancer. These bacteria are also used to boost the immune system and lower cholesterol.

Bifidobacterium Longum aid in B vitamin production, help remove cancer forming enzymes and consume fecal matter.  There is some evidence that longum is helpful in preventing infections after exposure to radiation. There is preliminary evidence that antibiotic-resistant Bifidobacterium longum can help improve short-term survival in the treatment of radiation sickness. In combination with antibiotics, bifidobacteria appear to help prevent dangerous bacteria from growing and causing a serious infection.

Takeda, Y., Nakase, H., Namba, K., Inoue, S., Ueno, S., Uza, N., and Chiba, T. Upregulation of T-bet and tight junction molecules by Bifidobactrium longum improves colonic inflammation of ulcerative colitis. Inflamm.Bowel.Dis. 2009;15:1617-1618. View NIH abstract of study.

Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P. A., Fahnestock, M., Moine, D., Berger, B., Huizinga, J. D., Kunze, W., McLean, P. G., Bergonzelli, G. E., Collins, S. M., and Verdu, E. F. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol.Motil. 2011;23:1132-1139. View NIH abstract of study.

Reddy, B. S. and Rivenson, A. Inhibitory effect of Bifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen. Cancer Res. 9-1-1993;53:3914-3918. View NIH abstract of study.

Matsumoto, T., Ishikawa, H., Tateda, K., Yaeshima, T., Ishibashi, N., and Yamaguchi, K. Oral administration of Bifidobacterium longum prevents gut-derived Pseudomonas aeruginosa sepsis in mice. J Appl.Microbiol. 2008;104:672-680. View NIH abstract of study.

Andrade, S. and Borges, N. Effect of fermented milk containing Lactobacillus acidophilus and Bifidobacterium longum on plasma lipids of women with normal or moderately elevated cholesterol. J.Dairy Res. 2009;76:469-474. View NIH abstract of study.

Iwabuchi, N., Xiao, J. Z., Yaeshima, T., and Iwatsuki, K. Oral administration of Bifidobacterium longum ameliorates influenza virus infection in mice. Biol.Pharm.Bull. 2011;34:1352-1355. View NIH abstract of study.

Lactobacillus rhamnosus has been widely studied in clinical trials for a variety of conditions and found to be safe.  Emerging therapies for diarrhea in HIV/AIDS patients may involve probiotics such as Lactobacillus rhamnosus GR-1, L. reuteri RC-14, and others.  It has also been shown to increase / build mucous membrane protection of the colon.

De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. View NIH abstract of study.

Sheih YH, Chiang BL, Wang LH, et al. Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001. J Am Coll Nutr 2001;20:149-56. View NIH abstract of study.

Gill HS, Rutherfurd KJ. Probiotic supplementation to enhance natural immunity in the elderly: effects of a newly characterized immunostimulatory strain of Lactobacillus rhamnosus HN001 (DR20) on leucocyte phagocytosis. Nutr Res 2001;21:183-9.

Alander M, Satokari R, Korpela R, et al. Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption. Appl Environ Microbiol 1999;65:351-4. View NIH abstract of study.

Lactobacillus Salivarius helps in the digestion of foods by breaking down the nutrients into more easily absorbable sizes. (It is particulary good at breaking down carbs.) It produces much needed enzymes which repair the intestinal tract and even eat crusted fecal matter.

Lactic acid bacteria (LAB) antimicrobial peptides typically exhibit antibacterial activity against food-borne pathogens, as well as spoilage bacteria. Therefore, they have attracted the greatest attention as tools for food biopreservation. In some countries LAB are already extensively used as probiotics in food processing and preservation.

LAB derived bacteriocins have been utilized as oral, topical antibiotics or disinfectants. Lactobacillus salivarius is a promising probiotic candidate commonly isolated from human, porcine, and avian gastrointestinal tracts (GIT), many of which are producers of unmodified bacteriocins of sub-classes IIa, IIb and IId.

It is a well-characterized bacteriocin producer and probiotic organism. Bacteriocins may facilitate the introduction of a producer into an established niche, directly inhibit the invasion of competing strains or pathogens, or modulate the composition of the microbiota and influence the host immune system.

Read more science about L salivarius...  Lactobacillus salivarius: Bacteriocin and probiotic activity

Lactobacillus Casei is able to survive wide ranges of temperature and PH. It helps improve digestion, reduce lactose intolerance and relieve constipation. Known to aid the growth of L.acidophilus. 

L casei is among the best-documented probiotics. L.casei, L. casei DN-114001, and L. casei  Shirota have been extensively studied.

L casei is a species of the genus Lactobacillus, which is found in the human intestine and mouth. This particular species of Lactobacillus is documented to have a wide pH and temperature range, and complements the growth of L acidophilus, a prolific producer of the much needed carbohydrate-digesting enzyme amylase.

Pedone CA, Arnaud CC, Postaire ER, et al. Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea. Int J Clin Pract 2000;54:589-71. View NIH abstract of study.

Pedone CA, Bernabeu AO, Postaire ER, et al. The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres. Int J Clin Pract 1999;53:179-84. View NIH abstract of study.

Isolauri E, Juntunen M, Rautanen T, et al. A human Lactobacillus strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children. Pediatrics 1991;8:90-7. View NIH abstract of study.

Bifidobacterium breve appears to aid constipation.  Recent preliminary research shows that taking Bifidobacterium breve reduced constipation in children 3-16 years of age.

Bifidobacteria belong to a group of bacteria called lactic acid bacteria. Lactic acid bacteria are found in fermented foods like yogurt and cheese. Bifidobacteria are used in treatment as so-called “probiotics,” the opposite of antibiotics. They are considered "friendly" bacteria and are taken to grow and multiply in areas of the body where they normally would occur. The human body counts on its normal bacteria to perform several jobs, including breaking down foods, helping the body take in nutrients, and preventing the take-over of “bad” bacteria. Probiotics such as bifidobacteria are typically used in cases when a disease occurs or might occur due to a kill-off of normal bacteria. For example, treatment with antibiotics can destroy disease-causing bacteria, but also normal bacteria in the GI (gastrointestinal) and urinary tracts. The theory is that taking Bifidobacterium probiotics during antibiotic treatment can prevent or minimize the death of good bacteria and the take-over by bad bacteria.

Lactobacillus plantarum is another beneficial bacteria, it's actually quite amazing.  It is commonly found in Korean kimchi, sauerkraut, cultured vegetables and in human saliva.

L. plantarum needs to flourish in your gut to keep pathogenic disease-causing microorganisms from overwhelming your gastrointestinal and immune systems.

So, as Dr Fedorak states, similar to the way icing coats a cake, L. plantarum creates a healthy barrier in your colon to keep dangerous bacteria from penetrating the lining of your intestines and entering your blood stream.  It is another well-documented, very safe "good" bacteria.

Niedzielin K, Kordecki H, Birkenfeld B. A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome. Eur J Gastroenterol Hepatol 2001;13:1143-7.  View NIH abstract of study.

Sen S, Mullan MM, Parker TJ, et al. Effect of Lactobacillus plantarum 299v on colonic fermentation and symptoms of irritable bowel syndrome. Dig Dis Sci 2002;47:2615-20. View NIH abstract of study.

Wullt M, Hagslatt ML, Odenholt I. Lactobacillus plantarum 299v for the treatment of recurrent Clostridium difficile-associated diarrhoea: a double-blind, placebo-controlled trial. Scand J Infect Dis 2003;35:365-7. . View NIH abstract of study.

NEWEST studies indicate:  Healthy Tummy = Healthy You!
Gut check with ProBio Plex!

  • Improves overall immunity -- kills harmful bacteria, boosts good bacteria
  • Good microflora eat bad bacteria, sugars, fats and built up fecal matter
  • Helps control IBS, Leaky Gut, Gas, Bloating, Yeast Overgrowth, Constipation, Diarhhea
  • Reduces lactose intolerance and lowers cholesterol naturally
  • Effective blend of key probiotics boosts gut health and immune system reaction

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